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Open Access Green as soon as Postprint is submitted to ZB.
Genomweite Assoziationsstudien (GWAS) - Möglichkeiten und Grenzen.
BioSpektrum 18, 508-510 (2012)
GWAS have brought many successes to detect DNA-variants for common diseases and other traits. Feasibility to genotype a large amount of SNPs cost efficiently in big populations with various study designs benefits GWAS in contrast to candidate gene studies. However, they only explain a small proportion of estimated heritability so far. It’s still a long way to go, to develop methods to discover false negative signals, find other impact e. g. from epigenetics or gene-environment interaction as well as to translate all findings into better understanding of disease and clinical practice.
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Publication type
Article: Journal article
Document type
Scientific Article
ISSN (print) / ISBN
0947-0867
e-ISSN
1868-6249
Journal
BioSpektrum
Quellenangaben
Volume: 18,
Issue: 5,
Pages: 508-510
Publisher
Springer
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Research Unit Molecular Epidemiology (AME)