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Ziegler, A.-G. ; Wallner, M. ; Kaiser, I.* ; Rossbauer, M. ; Harsunen, M.H. ; Lachmann, L.* ; Maier, J.M.* ; Winkler, C. ; Hummel, S.

Long-term protective effect of lactation on the development of type 2 diabetes in women with recent gestational diabetes mellitus.

Diabetes 61, 3167-3171 (2012)
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Women with gestational diabetes mellitus (GDM) have a high risk of developing postpartum type 2 diabetes. Strategies to prevent postpartum type 2 diabetes are important to reduce the epidemic of diabetes and its societal impact. Breastfeeding was reported to improve early postpartum glucose tolerance and reduce the subsequent risk of type 2 diabetes. To investigate whether breastfeeding influences short- and long-term postpartum diabetes outcomes, women with GDM (n = 304) participating in the prospective German GDM study were followed from delivery for up to 19 years postpartum for diabetes development. All participants were recruited between 1989 and 1999. Postpartum diabetes developed in 147 women and was dependent on the treatment received during pregnancy (insulin vs. diet), BMI, and presence/absence of islet autoantibodies. Among islet autoantibody-negative women, breastfeeding was associated with median time to diabetes of 12.3 years compared with 2.3 years in women who did not breastfeed. The lowest postpartum diabetes risk was observed in women who breastfed for >3 months. On the basis of these results, we recommend that breastfeeding should be encouraged among these women because it offers a safe and feasible low-cost intervention to reduce the risk of subsequent diabetes in this high-risk population. Diabetes 61:3167-3171, 2012
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Glucose-tolerance ; Duration ; Postpartum ; Predictors
ISSN (print) / ISBN 0012-1797
e-ISSN 1939-327X
Journal Diabetes
Quellenangaben Volume: 61, Issue: 12, Pages: 3167-3171 Article Number: , Supplement: ,
Publisher American Diabetes Association
Publishing Place Alexandria, VA.
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes Research (IDF)