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Hematopoiesis.
Cold Spring Harbor Perspect. Biol. 4:a008250 (2012)
Enormous numbers of adult blood cells are constantly regenerated throughout life from hematopoietic stem cells through a series of progenitor stages. Accessibility, robust functional assays, well-established prospective isolation, and successful clinical application made hematopoiesis the classical mammalian stem cell system. Most of the basic concepts of stem cell biology have been defined in this system. At the same time, many long-standing disputes in hematopoiesis research illustrate our still limited understanding. Here we discuss the embryonic development and lifelong maintenance of the hematopoietic system, its cellular components, and some of the hypotheses about the molecular mechanisms involved in controlling hematopoietic cell fates.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
STEM-CELL NICHE; TRANSCRIPTION FACTOR PAX5; HUMAN CORD BLOOD; COLONY-STIMULATING FACTOR; REGULATES SELF-RENEWAL; LINEAGE FATE DECISION; MOUSE BONE-MARROW; B-CELL; IN-VIVO; PROGENITOR CELLS
e-ISSN
1943-0264
Quellenangaben
Volume: 4,
Issue: 12,
Article Number: a008250
Publisher
Cold Spring Harbor Laboratory Press
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Research Unit Stem Cell Dynamics (SCD)