Home
Deutsch
Advanced Search
Browse by ...
Publication overview
Contact persons
Help
DOI
PMC
 |
|
Open Access Green as soon as Postprint is submitted to ZB.
The RNA-binding protein MARTA2 regulates dendritic targeting of MAP2 mRNAs in rat neurons.
J. Neurochem. 124, 670-684 (2013)
Dendritic targeting of mRNAs encoding the microtubule-associated protein 2 (MAP2) in neurons involves a cis-acting dendritic targeting element. Two rat brain proteins, MARTA1 and MARTA2, bind to the cis-element with both high affinity and specificity. In this study, affinity-purified MARTA2 was identified as orthologue of human far-upstream element binding protein 3. In neurons, it resides in somatodendritic granules and dendritic spines and associates with MAP2 mRNAs. Expression of a dominant-negative variant of MARTA2 disrupts dendritic targeting of endogenous MAP2 mRNAs, while not noticeably altering the level and subcellular distribution of polyadenylated mRNAs as a whole. Finally, MAP2 transcripts associate with the microtubule based motor KIF5 and inhibition of KIF5 but not cytoplasmic dynein function disrupts extrasomatic trafficking of MAP2 mRNA granules. Thus, in neurons MARTA2 appears to represent a key trans-acting factor involved in KIF5c-mediated dendritic targeting of MAP2 mRNAs.
Altmetric
Additional Metrics?
Edit extra informations
Login
Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Microtubule; RNA transport; trans-acting factor; ribonucleoprotein particle; molecular motor; kinesin; Mental-retardation Protein ; Single-stranded-dna ; Ribonucleoprotein Complexes ; Cytoplasmic Localization ; Kh Domains ; Transport ; Translation ; Element ; Ksrp ; Expression
ISSN (print) / ISBN
0022-3042
e-ISSN
1471-4159
Journal
Journal of Neurochemistry
Quellenangaben
Volume: 124,
Issue: 5,
Pages: 670-684
Publisher
Wiley
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Molecular Immunology (IMI)