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Preparation of Ca-alginate biopolymer beads and investigation of their decorporation characteristics for 85Sr, 238U and 234Th by in vitro experiments.
Radiat. Prot. Dosim. 153, 47-55 (2013)
The aim of this work was to investigate whether Ca-alginate biopolymer beads (CaABBs) can be used to reduce the bioavailability of radionuclides in the gastrointestinal tract of humans. The uptake of strontium, uranium and thorium from a simulated gastrointestinal system was studied by in vitro techniques using CaABBs. This agent was prepared from Na-alginate through cross-linking with divalent calcium ions according to the egg-box model. The effects of process variables such as pH of the gastrointestinal juice, incubation time and solid-to-solution ratio for the removal of radionuclides from the gastrointestinal juice were investigated. The results suggest that CaABBs are a potent material for reducing the bioavailability of radionuclides with a high uptake efficiency in the gastrointestinal tract.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Chelating-agents ; Biosorption ; Metals ; Rats ; Bioaccessibility ; Radiostrontium ; Uranium(vi) ; Absorption ; Speciation ; Efficacy
Language
english
Publication Year
2013
HGF-reported in Year
2013
ISSN (print) / ISBN
0144-8420
e-ISSN
1742-3406
Journal
Radiation Protection Dosimetry
Quellenangaben
Volume: 153,
Issue: 1,
Pages: 47-55
Publisher
Oxford University Press
Publishing Place
Oxford
Reviewing status
Peer reviewed
Institute(s)
Institute of Radiation Protection (ISS)
Research Unit Medical Radiation Physics and Diagnostics (AMSD)
Research Unit Medical Radiation Physics and Diagnostics (AMSD)
POF-Topic(s)
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Research field(s)
Radiation Sciences
PSP Element(s)
G-501100-002
G-503600-001
G-503600-001
PubMed ID
22648239
WOS ID
WOS:000312881800004
Scopus ID
84871573166
Erfassungsdatum
2013-01-01