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Open Access Green as soon as Postprint is submitted to ZB.
MALDI imaging mass spectrometry for direct tissue analysis.
Methods Mol. Biol. 931, 537-546 (2013)
MALDI (Matrix-Assisted Laser Desorption/Ionization) Imaging mass spectrometry is a powerful new method for analyzing the spatial distribution of molecules in tissues. Several different classes of cellular constituents such as proteins, peptides, lipids, and small molecules can be analyzed in situ while maintaining the morphological integrity of the tissue. This allows a correlation of the morphology with the previously acquired molecular patterns. By this, specific molecules can be clearly assigned to their cellular origin. Here, we will present a protocol for the analysis of proteins in tissues which are either native or alcohol-fixed and paraffin-embedded.
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Publication type
Article: Journal article
Document type
Scientific Article
Editors
Taatjes, D.J.* ; Roth, J.*
Keywords
MALDI Imaging; Imaging mass spectrometry; In situ proteomics; Tissue proteomics; Morphology-based tissue analysis
ISSN (print) / ISBN
1064-3745
e-ISSN
1940-6029
Conference Title
Cell Imaging Techniques : Methods and Protocols
Journal
Methods in Molecular Biology
Quellenangaben
Volume: 931,
Pages: 537-546
Series
Methods in Molecular Biology
Publisher
Springer
Publishing Place
Berlin [u.a.]
Reviewing status
Peer reviewed