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Open Access Green as soon as Postprint is submitted to ZB.
Current strategies in immunotherapy for acute myeloid leukemia.
Immunotherapy 5, 63-78 (2013)
The prognosis of acute myeloid leukemia, particularly when associated with adverse chromosomal or molecular aberrations, is poor due to a high relapse rate after induction chemotherapy. Postremission therapy for elimination of minimal residual disease remains a major challenge. Allogeneic hematopoietic stem cell transplantation has proven to provide a potent antileukemic effect. Novel strategies are needed for patients ineligible for this treatment. Here current immunotherapeutic concepts in acute myeloid leukemia in a nonallogeneic hematopoietic stem cell transplantation setting are reviewed. Data gathered with different monoclonal antibodies are discussed. Adoptive transfer of NK and T cells is reviewed, including evolving data on T-cell engineering. Results of systemic cytokine administration and of therapeutic vaccinations with peptides, modified leukemic cells and dendritic cells are presented. One particular focus of this review is the integration of currently running clinical trials. Recent immunotherapeutic studies have been encouraging and further interesting results are to be expected.
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Publication type
Article: Journal article
Document type
Review
Keywords
acute myeloid leukemia; adoptive cellular therapy; chimeric antigen receptor; dendritic cell vaccination; gemtuzumab ozogamicin; immunotherapy; monoclonal antibody; peptide vaccination; TCR-transgenic; T cell; WT1 PEPTIDE VACCINATION; T-CELL RESPONSES; ACUTE MYELOGENOUS LEUKEMIA; TUMOR PROTEIN-1 WT1; CHIMERIC-ANTIGEN-RECEPTOR; DENDRITIC CELLS; STEM-CELLS; GEMTUZUMAB OZOGAMICIN; COMPLETE REMISSION; ELDERLY-PATIENTS
ISSN (print) / ISBN
1750-743X
e-ISSN
1750-7448
Journal
Immunotherapy
Quellenangaben
Volume: 5,
Issue: 1,
Pages: 63-78
Publisher
Future Medicine
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
CCG Hematopoetic Cell Transplants (IMI-KHZ)
CCG Pathogenesis of Acute Myeloid Leukemia (KKG-KPL)
CCG Pathogenesis of Acute Myeloid Leukemia (KKG-KPL)