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Allebrandt, K.V.* ; Amin, N.* ; Müller-Myhsok, B.* ; Esko, T.* ; Teder-Laving, M.* ; Azevedo, R.V.* ; Hayward, C.* ; van Mill, J.* ; Vogelzangs, N.* ; Green, E.W.* ; Melville, S.A.* ; Lichtner, P. ; Wichmann, H.-E. ; Oostra, B.A.* ; Janssens, A.C.* ; Campbell, H.* ; Wilson, J.F.* ; Hicks, A.A.* ; Pramstaller, P.P.* ; Dogas, Z.* ; Rudan, I.* ; Merrow, M.* ; Penninx, B.* ; Kyriacou, C.P.* ; Metspalu, A.* ; van Duijn, C.M.* ; Meitinger, T. ; Roenneberg, T.*

A KATP channel gene effect on sleep duration: From genome-wide association studies to function in Drosophila.

Mol. Psychiatry 18, 122-132 (2013)
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Humans sleep approximately a third of their lifetime. The observation that individuals with either long or short sleep duration show associations with metabolic syndrome and psychiatric disorders suggests that the length of sleep is adaptive. Although sleep duration can be influenced by photoperiod (season) and phase of entrainment (chronotype), human familial sleep disorders indicate that there is a strong genetic modulation of sleep. Therefore, we conducted high-density genome-wide association studies for sleep duration in seven European populations (N=4251). We identified an intronic variant (rs11046205; P=3.99 × 10(-8)) in the ABCC9 gene that explains ≈5% of the variation in sleep duration. An influence of season and chronotype on sleep duration was solely observed in the replication sample (N=5949). Meta-analysis of the associations found in a subgroup of the replication sample, chosen for season of entry and chronotype, together with the discovery results showed genome-wide significance. RNA interference knockdown experiments of the conserved ABCC9 homologue in Drosophila neurons renders flies sleepless during the first 3 h of the night. ABCC9 encodes an ATP-sensitive potassium channel subunit (SUR2), serving as a sensor of intracellular energy metabolism.
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Publication type Article: Journal article
Document type Scientific Article
Keywords ABCC9; chronotype; Munich Chrono Type Questionnaire; seasonality; sleep duration; SUR
Language
Publication Year 2013
HGF-reported in Year 2013
ISSN (print) / ISBN 1359-4184
e-ISSN 1476-5578
Journal Molecular Psychiatry
Quellenangaben Volume: 18, Issue: 1, Pages: 122-132 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Reviewing status Peer reviewed
Institute(s) Institute of Human Genetics (IHG)
Institute of Epidemiology (EPI)
Institute of Genetic Epidemiology (IGE)
POF-Topic(s) 30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
Research field(s) Genetics and Epidemiology
PSP Element(s) G-500700-001
G-503900-002
G-504100-001
DOI 10.1038/mp.2011.142
Scopus ID 84871309889
PubMed ID 22105623
Erfassungsdatum 2013-01-23
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