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Horikoshi, M.* ; Yaghootkar, H.* ; Mook-Kanamori, D.O.* ; Sovio, U.* ; Taal, H.R.* ; Hennig, B.J.* ; Bradfield, J.P.* ; St Pourcain, B.* ; Evans, D.M* ; Charoen, P.* ; Kaakinen, M.* ; Cousminer, D.L.* ; Lehtimäki, T.* ; Kreiner-Møller, E.* ; Warrington, N.M.* ; Bustamante, M.* ; Feenstra, B.* ; Berry, D.J.* ; Thiering, E. ; Pfab, T.* ; Barton, S.J.* ; Shields, B.M.* ; Kerkhof, M.* ; van Leeuwen, E.M.* ; Fulford, A.J.* ; Kutalik, Z.* ; Zhao, J.H.* ; den Hoed, M.* ; Mahajan, A.* ; Lindi, V.* ; Goh, L.K.* ; Hottenga, J.J.* ; Wu, Y.* ; Raitakari, O.T.* ; Harder, M.N.* ; Meirhaeghe, A.* ; Ntalla, I.* ; Salem, R.M.* ; Jameson, K.A.* ; Zhou, K.* ; Monies, D.M.* ; Lagou, V.* ; Kirin, M.* ; Heikkinen, J.* ; Adair, L.S.* ; Alkuraya, F.S.* ; Al-Odaib, A.* ; Amouyel, P.* ; Andersson, E.A.* ; Bennett, A.J.* ; Blakemore, A.I. ; Buxton, J.L.* ; Dallongeville, J.* ; Das, S.* ; de Geus, E.J.* ; Estivill, X.* ; Flexeder, C.* ; Froguel, P.* ; Geller, F.* ; Godfrey, K.M.* ; Gottrand, F.* ; Groves, C.J.* ; Hansen, T.* ; Hirschhorn, J.N.* ; Hofman, A.* ; Hollegaard, M.V.* ; Hougaard, D.M.* ; Hyppönen, E.* ; Inskip, H.M.* ; Isaacs, A.* ; Jørgensen, T.* ; Kanaka-Gantenbein, C.* ; Kemp, J.P.* ; Kiess, W.* ; Kilpeläinen, T.O.* ; Klopp, N. ; Knight, B.A.* ; Kuzawa, C.W.* ; McMahon, G.* ; Newnham, J.P.* ; Niinikoski, H.* ; Oostra, B.A.* ; Pedersen, L.* ; Postma, D.S.* ; Ring, S.M.* ; Rivadeneira, F.* ; Robertson, N.R.* ; Sebert, S.* ; Simell, O.* ; Slowinski, T.* ; Tiesler, C.M. ; Tönjes, A.* ; Vaag, A.* ; Viikari, J.S.* ; Vink, J.M.* ; Vissing, N.H.* ; Wareham, N.J.* ; Willemsen, G.* ; Witte, D.R.* ; Zhang, H.* ; Zhao, J.* ; MAGIC Consortium (Wichmann, H.-E. ; Thorand, B. ; Illig, T. ; Grallert, H. ; Meisinger, C. ; Gieger, C.) ; Early Growth Genetics Consortium (*) ; Wilson, J.F.* ; Stumvoll, M.* ; Prentice, A.M.* ; Meyer, B.F.* ; Pearson, E.R.* ; Boreham, C.A.* ; Cooper, C.* ; Gillman, M.W.* ; Dedoussis, G.V.* ; Moreno, L.A.* ; Pedersen, O.* ; Saarinen, M.* ; Mohlke, K.L.* ; Boomsma, D.I.* ; Saw, S.M.* ; Lakka, T.A.* ; Körner, A.* ; Loos, R.J.* ; Ong, K.K.* ; Vollenweider, P.* ; van Duijn, C.M.* ; Koppelman, G.H.* ; Hattersley, A.T.* ; Holloway, J.W.* ; Hocher, B.* ; Heinrich, J. ; Power, C.* ; Melbye, M.* ; Guxens, M.* ; Pennell, C.E.* ; Bønnelykke, K.* ; Bisgaard, H.* ; Eriksson, J.G.* ; Widen, E.* ; Hakonarson, H.* ; Uitterlinden, A.G.* ; Pouta, A.* ; Lawlor, D.A.* ; Smith, G.D.* ; Frayling, T.M.* ; McCarthy, M.I.* ; Grant, S.F.* ; Jaddoe, V.W.* ; Jarvelin, M.R.* ; Timpson, N.J.* ; Prokopenko, I.* ; Freathy, R.M.*

New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism.

Nat. Genet. 45, 76-82 (2013)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Birth weight within the normal range is associated with a variety of adult-onset diseases, but the mechanisms behind these associations are poorly understood. Previous genome-wide association studies of birth weight identified a variant in the ADCY5 gene associated both with birth weight and type 2 diabetes and a second variant, near CCNL1, with no obvious link to adult traits. In an expanded genome-wide association meta-analysis and follow-up study of birth weight (of up to 69,308 individuals of European descent from 43 studies), we have now extended the number of loci associated at genome-wide significance to 7, accounting for a similar proportion of variance as maternal smoking. Five of the loci are known to be associated with other phenotypes: ADCY5 and CDKAL1 with type 2 diabetes, ADRB1 with adult blood pressure and HMGA2 and LCORL with adult height. Our findings highlight genetic links between fetal growth and postnatal growth and metabolism.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords GENOME-WIDE ASSOCIATION; TYPE-2 DIABETES RISK; SUSCEPTIBILITY LOCI; COMMON VARIANTS; BLOOD-PRESSURE; FASTING GLUCOSE; HEAD CIRCUMFERENCE; GLUCOKINASE GENE; METAANALYSIS; INDIVIDUALS
ISSN (print) / ISBN 1061-4036
e-ISSN 1546-1718
Journal Nature Genetics
Quellenangaben Volume: 45, Issue: 1, Pages: 76-82 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Publishing Place New York, NY
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)
Institute of Genetic Epidemiology (IGE)
Research Unit Molecular Epidemiology (AME)