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Brockow, I. ; Zutavern, A. ; Hoffmann, U.* ; Grubl, A.* ; von Berg, A.* ; Koletzko, S.* ; Filipiak, B. ; Bauer, C.P.* ; Wichmann, H.-E. ; Reinhardt, D.* ; Berdel, D.* ; Krämer, U.* ; Heinrich, J.

Early allergic sensitizations and their relevance to atopic diseases in children aged 6 years: Results of the GINI study.

J. Invest. Allergol. Clin. Immunol. 19, 180-187 (2009)
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Background: Only a few studies have analyzed the value of early sensitization in predicting the development of atopic disease. The relevance of low immunoglobulin (Ig) E antibody levels in this respect also remains unclear. Objective: To investigate the relevance of sensitization in 12-month-old children in the development of atopic disease by the age of 6 years. Methods: We analyzed data for 1290 children with a positive family history of atopy from the prospective, multicenter German Infant Nutritional Intervention (GINIplus) study and investigated the relationship between the presence of detectable specific IgE antibodies at the age of 12 months and the development of atopic disease by the age of 6 years. Results: In all, 10.9% of children analyzed developed sensitization. At the age of 6 years, 20.6% of children with early sensitization had eczema compared to 9.4% of those without (odds ratio [OR], 2.31; 95% confidence interval [CI), 1.42-3.74). The corresponding figures were 15.4% vs 7.3% for allergic rhinitis (OR, 2.22; CI, 1.31-3.78) and 10.2% vs 2.6% (OR, 3.93; 95% Cl, 1.98-7.76) for asthma. Children with early sensitization to aeroallergens had the greatest risk of subsequent atopic disease. Early sensitization did not increase risk in children without eczema within the first year of life. Very low specific IgE levels (0.18-0.34 kU/L) were not significantly associated with any of the outcomes analyzed. Conclusion: Sensitization to common food allergens and to aeroallergens in particular during the first year of life was found to be a strong predictor for the development of atopic disease by the age of 6 years in children with a positive family history of atopy.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Atopic disease; Children; GINI study; Low immunoglobulin E (IgE) levelS.; Sensitization; house-dust mite; high-risk children; birth cohort; follow-up; inhalant allergenS.; primary prevention; ige antibodieS.; young-children; food allergy; cat allergen; HOUSE-DUST MITE; HIGH-RISK CHILDREN; BIRTH COHORT; FOLLOW-UP; INHALANT ALLERGENS; PRIMARY PREVENTION; IGE ANTIBODIES; YOUNG-CHILDREN; FOOD ALLERGY; CAT ALLERGEN
ISSN (print) / ISBN 1018-9068
e-ISSN 1698-0808
Journal Journal of Investigational Allergology and Clinical Immunology
Quellenangaben Volume: 19, Issue: 3, Pages: 180-187 Article Number: , Supplement: ,
Publisher ESMON Publicidad
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)