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Open Access Green as soon as Postprint is submitted to ZB.
Use of the individual data of the a-bomb survivors for biologically based cancer models.
Radiat. Environ. Biophys. 49, 39-46 (2010)
All recent analyses of the data on solid cancer incidence of the atomic bomb survivors are corrected for migration and random dose errors. In the usual treatment with grouped data and regression calibration, the calibration of doses depends on the used dose response. For solid cancers, it usually is linear. Here, an individual likelihood is presented which works without further adjustment for all dose responses. When the same assumptions are made as in the usual Poisson regression, equivalent results are obtained. But, the individual likelihood has the potential to use more detailed models for dose errors and to estimate non-linear dose responses without recalibration. As an example for the potential of the individual data set for the analysis of risk at low doses, signals for a saturating bystander effect are investigated.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
atomic bomb survivers; individual likelihood; dose uncertainties; low dose; bystander effect
Language
english
Publication Year
2010
Prepublished in Year
2009
HGF-reported in Year
2010
ISSN (print) / ISBN
0301-634X
e-ISSN
1432-2099
Quellenangaben
Volume: 49,
Issue: 1,
Pages: 39-46
Publisher
Springer
Reviewing status
Peer reviewed
Institute(s)
Institute of Radiation Protection (ISS)
POF-Topic(s)
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Research field(s)
Radiation Sciences
PSP Element(s)
G-501100-006
PubMed ID
19908056
Scopus ID
77049127994
Erfassungsdatum
2009-12-31