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Complete angle small animal fluorescence imaging with early-arriving photons.
Conf. Proc. IEEE Eng. Med. Biol. Soc., 6331-6334 (2009)
Fluorescence mediated tomography allows quantitative, three-dimensional imaging of optical reporter probes in whole animals and is therefore emerging as a powerful molecular imaging tool. The achievable image quality in fluorescence tomography is limited by the high-degree of light scatter in biological tissue. Time-gated detection of early-arriving and therefore minimally-scattered photons transmitted through diffusive tissue is one strategy for minimizing the effects of light scatter. In this work, we performed full-angle tomographic imaging of mice implanted with fluorescent tubes using time-gated detection of early- and later-arriving photons. This was achieved using a femtosecond laser and a high-speed, time-gated intensified CCD imager. We demonstrate that the early-transmitted fluorescent photons allow improved visualization of the fluorescence distribution, even when considering individual projections through the animal. High-fidelity image reconstruction using 72 projections in 5-degree steps using early-arriving photons is also demonstrated.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
optical imaging; optical tomography; fluorescence
ISSN (print) / ISBN
1557-170X
Conference Title
31st Annual International Conference of the IEEE EMBS Mineapolis, Minnesota, USA, September 2-6, 2009
Quellenangaben
Pages: 6331-6334
Publisher
Institute of Electrical and Electronics Engineers (IEEE)
Publishing Place
Minneapolis, MN
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Biological and Medical Imaging (IBMI)