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Open Access Gold as soon as Publ. Version/Full Text is submitted to ZB.
Hybrid FMT-CT imaging of amyloid-β plaques in a murine Alzheimer's disease model.
Neuroimage 44, 1304-1311 (2009)
The need to study molecular and functional parameters of Alzheimer's disease progression in animal models has led to the development of disease-specific fluorescent markers. However, curved optical interfaces and a highly heterogeneous internal structure make quantitative fluorescence imaging of the murine brain a particularly challenging tomographic problem. We investigated the integration of X-ray computed tomography (CT) information into a state-of-the-art fluorescence molecular tomography (FMT) scheme and establish that the dual-modality approach is essential for high fidelity reconstructions of distributed fluorescence within the murine brain, as compared to conventional fluorescence tomography. We employ this method in vivo using a fluorescent oxazine dye to quantify amyloid-beta plaque burden in transgenic APP23 mice modeling Alzheimer's disease. Multi-modal imaging allows for accurate signal localization and correlation of in vivo findings to ex vivo studies. The results point to FMT-CT as an essential tool for in vivo study of neurodegenerative disease in animal models and potentially humans.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
diffuse optical tomography; fluorescence molecular tomography; laplacian-type regularization; human brain-function; transgenic mice; precursor protein; mouse model; born ratio; in-vivo; reconstruction
ISSN (print) / ISBN
1053-8119
e-ISSN
1095-9572
Quellenangaben
Volume: 44,
Issue: 4,
Pages: 1304-1311
Publisher
Elsevier
Reviewing status
Peer reviewed
Institute(s)
Institute of Biological and Medical Imaging (IBMI)