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Open Access Green as soon as Postprint is submitted to ZB.
Air pollution and lung function in the European Community Respiratory Health Survey.
Int. J. Epidemiol. 37, 1349-1358 (2008)
BACKGROUND: The association of long-term air pollution and lung function has not been studied across adult European multi-national populations before. The aim of this study was to determine the association between long-term urban background air pollution and lung function levels, as well as change in lung function among European adults. METHODS: Forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and the ratio thereof (FEV1/FVC) were assessed at baseline and after 9 years of follow-up in adults from 21 European centres (followed-up sample 5610). Fine particles (PM(2.5)) were measured in 2000/2001 using central monitors. RESULTS: Despite sufficient statistical power no significant associations were found between city-specific annual mean PM(2.5) and average lung function levels. The findings also do not support an effect on change in lung function, albeit statistical power was insufficient to significantly detect such an association. CONCLUSIONS: The inability to refuse the null hypothesis may reflect (i) no effect of urban air pollution on lung function or (ii) inherent biases due to the study design. Examples of the latter are lack of individual-level air quality assignment, not quantified within-city contrasts in traffic-related pollution, or the heterogeneity of the studied populations and their urban environments. Future studies on long-term effects of air pollution on lung function could increase statistical power and reduce potential misclassification and confounding by characterizing exposure on the level of individuals, capturing contrasts due to local sources, in particular traffic.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
PM2.5; FEV1; FVC; adults; longitudinal; multilevel
Language
english
Publication Year
2008
HGF-reported in Year
2009
ISSN (print) / ISBN
0300-5771
e-ISSN
1464-3685
Quellenangaben
Volume: 37,
Issue: 6,
Pages: 1349-1358
Publisher
Oxford University Press
Reviewing status
Peer reviewed
Institute(s)
Institute of Epidemiology (EPI)
PSP Element(s)
G-503900-002
PubMed ID
18593748
Scopus ID
57349097584
Erfassungsdatum
2009-09-21