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Willer, C.J.* ; Speliotes, E.K.* ; Loos, R.J.F.* ; Li, S.X.* ; Lindgren, C.M.* ; Heid, I.M. ; Berndt, S.I.* ; Elliott, A..L.* ; Jackson, A.U.* ; Lamina, C. ; Lettre, G.* ; Lim, N.* ; Lyon, H.N.* ; McCarroll, S.A.* ; Papadakis, K.* ; Qi, L.* ; Randall, J.C.* ; Roccasecca, R.M.* ; Sanna, S.* ; Scheet, P.* ; Weedon, M.N.* ; Wheeler, E.* ; Zhao, J.H.* ; Jacobs, L.C.* ; Prokopenko, I.* ; Soranzo, N.* ; Tanaka, T.* ; Timpson, N.J.* ; Almgren, P.* ; Bennett, A.* ; Bergman, R.N.* ; Bingham, S.A.* ; Bonnycastle, L.L.* ; Brown, M.* ; Burtt, N.L.P.* ; Chines, P.* ; Coin, L.* ; Collins, F.S.* ; Connell, J.M.* ; Cooper, C.* ; Smith, G.D.* ; Dennison, E.M.* ; Deodhar, P.* ; Elliott, P.* ; Erdos, M.R.* ; Estrada, K.* ; Evans, D.M* ; Gianniny, L.* ; Gieger, C. ; Gillson, C.J.* ; Guiducci, C.* ; Hackett, R.* ; Hadley, D.* ; Hall, A.S.* ; Havulinna, A.S.* ; Hebebrand, J.* ; Hofman, A.* ; Isomaa, B.* ; Jacobs, K.B.* ; Johnson, T.* ; Jousilahti, P.* ; Jovanovic, Z.* ; Khaw, K.T.* ; Kraft, P.* ; Kuokkanen, M.* ; Kuusisto, J.* ; Laitinen, J.* ; Lakatta, E.G.* ; Luan, J.* ; Luben, R.N.* ; Mangino, M.* ; McArdle, W.L.* ; Meitinger, T. ; Mulas, A.* ; Munroe, P.B.* ; Narisu, N.* ; Ness, A.R.* ; Northstone, K.* ; O'Rahilly, S.* ; Purmann, C.* ; Rees, M.G.* ; Ridderstraale, M.* ; Ring, S.M.* ; Rivadeneira, F.* ; Ruokonen, A.* ; Sandhu, M.S.* ; Saramies, J.* ; Scott, L.J.* ; Scuteri, A.* ; Silander, K.* ; Sims, M.A.* ; Song, K.* ; Stephens, J.* ; Stevens, S.* ; Stringham, H.M.* ; Tung, Y.C.L.* ; Valle, T.T.* ; van Duijn, C.M.* ; Vimaleswaran, K.S.* ; Vollenweider, P.* ; Waeber, G.* ; Wallace, C.* ; Watanabe, R.M.* ; Waterworth, D.M.* ; Watkins, N.* ; Witteman, J.C.M.* ; Zeggini, E.* ; Zhai, G.J.* ; Zillikens, M.C.* ; Altshuler, D.* ; Caulfield, M.J.* ; Chanock, S.J.* ; Farooqi, I.S.* ; Ferrucci, L.* ; Guralnik, J.M.* ; Hattersley, A.T.* ; Hu, F.B.* ; Jarvelin, M.R.* ; Laakso, M.* ; Mooser, V.* ; Ong, K.K.* ; Ouwehand, W.H.* ; Salomaa, V.* ; Samani, N.J.* ; Spector, T.D.* ; Tuomi, T.* ; Tuomilehto, J.* ; Uda, M.* ; Uitterlinden, A.G.* ; Wareham, N.J.* ; Deloukas, P.* ; Frayling, T.M.* ; Groop, L.C.* ; Hayes, R.B.* ; Hunter, D.J.* ; Mohlke, K.L. ; Peltonen, L.* ; Schlessinger, D.* ; Strachan, D.P.* ; Wichmann, H.-E. ; McCarthy, M.I.* ; Boehnke, M.* ; Barroso, I.* ; Abecasis, G.R.* ; Hirschhorn, J.N.*

Six new loci associated with body mass index highlight a neuronal influence on body weight regulation.

Nat. Genet. 41, 25-34 (2009)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Common variants at only two loci, FTO and MC4R, have been reproducibly associated with body mass index (BMI) in humans. To identify additional loci, we conducted meta-analysis of 15 genome-wide association studies for BMI (n > 32,000) and followed up top signals in 14 additional cohorts (n > 59,000). We strongly confirm FTO and MC4R and identify six additional loci (P < 5 x 10(-8)): TMEM18, KCTD15, GNPDA2, SH2B1, MTCH2 and NEGR1 (where a 45-kb deletion polymorphism is a candidate causal variant). Several of the likely causal genes are highly expressed or known to act in the central nervous system (CNS), emphasizing, as in rare monogenic forms of obesity, the role of the CNS in predisposition to obesity.
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Publication type Article: Journal article
Document type Scientific Article
Keywords genome-wide association; coronary-artery-disease; alcohol dependence; common variants; gene-expression; fto gene; neurite outgrowth; childhood obesity; adult obesity; mice
Language english
Publication Year 2009
HGF-reported in Year 0
ISSN (print) / ISBN 1061-4036
e-ISSN 1546-1718
Journal Nature Genetics
Quellenangaben Volume: 41, Issue: 1, Pages: 25-34 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Publishing Place New York, NY
Reviewing status Peer reviewed
Institute(s) Institute of Human Genetics (IHG)
Institute of Epidemiology (EPI)
POF-Topic(s) 30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
30503 - Chronic Diseases of the Lung and Allergies
Research field(s) Genetics and Epidemiology
PSP Element(s) G-500700-001
G-503900-001
PubMed ID 19079261
DOI 10.1038/ng.287
Scopus ID 58149163142
Erfassungsdatum 2009-07-09
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