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Open Access Green as soon as Postprint is submitted to ZB.
Polymorphisms in the receptor for GDNF (RET) are not associated with Parkinson's disease in Southern Germany.
Neurobiol. Aging 31, 167-168 (2010)
The aetiology of the selective neurodegeneration in Parkinson's disease (PD) is still unknown. Neurotrophic factors, e.g. glial cell line-derived neurotrophic factor (GDNF), have been shown to promote survival of dopaminergic neurons. Interestingly, aged mice lacking GDNF-receptor (RET) in their dopaminergic neurons show a phenotype similar to presymptomatic PD. We therefore were interested whether polymorphisms in the RET gene were associated with increased PD risk. Analyzing 25 SNPs in the RET region in 340 Southern German PD patients and 340 age- and sex-matched controls from Southern Germany (KORA S4), we did not find any significant association with PD, suggesting that the equilibrium of trophic factors in PD might be disturbed on other levels than the genomic encoding.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Ret; GDNF; Parkinson's disease; Genetic association
ISSN (print) / ISBN
0197-4580
e-ISSN
1558-1497
Journal
Neurobiology of Aging
Quellenangaben
Volume: 31,
Issue: 1,
Pages: 167-168
Publisher
Elsevier
Publishing Place
New York, NY [u.a.]
Non-patent literature
Publications
Reviewing status
Peer reviewed