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Jacob, P. ; Meckbach, R. ; Kaiser, J.C. ; Sokolnikov, M.*

Possible expressions of radiation-induced genomic instability, bystander effects or low-dose hypersensitivity in cancer epidemiology.

Mutat. Res. -Fund. Mol. Mech. Mutag. 687, 34-39 (2010)

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Open Access Green as soon as Postprint is submitted to ZB.

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Recent publications on the integration of radiobiological effects in the two-step clonal expansion (TSCE) model of carcinogenesis and applications to radioepidemiological data are reviewed and updated. First, a model version with radiation-induced genomic instability was shown to be a possible explanation for the age dependence of the radiation-induced cancer mortality in the Techa River Cohort. Second, it is demonstrated that inclusion of a bystander effect with a dose threshold allows an improved description of the lung cancer mortality risk for the Mayak workers cohort due to incorporation of plutonium. The threshold for the annual lung dose is estimated to 12 (90%CI: 4; 14)mGy/year. This threshold applies to the initiation of preneoplastic cells and to hyperplastic growth. There is, however, no evidence for a threshold for the effects of gamma radiation. Third, models with radiation-induced cell inactivation tend to predict lower cancer risks among the atomic bomb survivors with exposure at young age than conventionally used empirical models. Also, risks after exposures with doses in the order of 100mGy are predicted to be higher in models with low-dose hypersensitivity than in models with conventional cell survival curves. In the reviewed literature, models of carcinogenesis tend to describe radioepidemiological data better than conventionally used empirical models.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Carcinogenesis; Ionizing radiation; Genomic-instability; Bystander effect; Low-dose hypersensitivity; Cancer risk

ISSN (print) / ISBN 0027-5107

e-ISSN 1873-135X

Journal Mutation Research / Fundamental and Molecular Mechanisms of Mutagenesis

Quellenangaben Volume: 687, Issue: 1-2, Pages: 34-39

Publisher Elsevier

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Radiation Protection (ISS)