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Mindnich, R.* ; Adamski, J.

Zebrafish 17β-hydroxysteroid dehydrogenases: An evolutionary perspective.

Mol. Cell. Endocrinol. 301, (Sp. Iss. SI), 20-26 (2009)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
The term 17beta-hydroxysteroid dehydrogenase (17beta-HSD) describes an enzyme that stereospeciflcally reduces or oxidizes a keto- or hydroxy group at C17 of the steroid scaffold, respectively. Fourteen mammalian 17beta-HSDs have been identified so far and nine sequence homologs are found in zebrafish. 17beta-HSDs additionally active in fatty acid metabolism display high sequence conservation and widespread tissue expression. Homologs of these multifunctional 17beta-HSDs have been identified in flies, worms and yeast, and steroid-converting activity was demonstrated in some cases. The "classical" 17beta-HSDs, types 1, 2 and 3, are steroid-specific enzymes expressed in few tissues. They may have arisen at the beginning of vertebrate evolution allowing new, differently controlled modes of steroid hormone action. These findings reflect on two aspects: (1) the evolutionary origin of steroid-specific enzymes and (2) a possible conservation of steroid hormone function in invertebrates through currently unknown mechanisms.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords 17beta-hydroxysteroid dehydrogenase (17beta-HSD); Steroids; Fatty acids; Zebrafish; Evolution; human 17-beta-hydroxysteroid dehydrogenases; major histocompatibility complex; coenzyme-a dehydrogenase; fatty-acid elongase; breast-cancer; 3-ketosteroid reductase; caenorhabditis-elegans; tissue distribution; estrogen-receptor; molecular-cloning
ISSN (print) / ISBN 0303-7207
e-ISSN 1872-8057
Journal Molecular and Cellular Endocrinology
Quellenangaben Volume: 301, Issue: 1-2, Pages: 20-26, Article Number: , Supplement: (Sp. Iss. SI)
Publisher Elsevier
Publishing Place Shannon
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Molekulare Endokrinologie und Metabolismus (MEM)