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Open Access Green as soon as Postprint is submitted to ZB.
Further delineation of the association signal on chromosome 5 from the first whole genome association study in Parkinson's disease.
Neurobiol. Aging 30, 1706-1709 (2009)
A recently published whole genome association study showed the involvement of 13 SNPs in the pathogenesis of Parkinson disease (PD). We performed a replication study to assess their involvement in our sporadic cohort consisting of 663 cases and 1002 controls ascertained from Germany. One of the previously reported SNP, rs7723605, showed evidence of association (p value 0.04) in our sample. We further refined the signal by genotyping additional 22 SNPs around SNP rs7723605. Our refinement analysis, however, did not provide evidence for association in our sample after adjusting for multiple testing by permutation procedure. In conclusion, our study did not lend support to the finding that the reported SNPs are directly influencing the susceptibility to sporadic form of PD at least in our population.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Parkinson disease; Whole genome association; Linkage disequilibrium (LD)
ISSN (print) / ISBN
0197-4580
e-ISSN
1558-1497
Journal
Neurobiology of Aging
Quellenangaben
Volume: 30,
Issue: 10,
Pages: 1706-1709
Publisher
Elsevier
Publishing Place
New York, NY [u.a.]
Non-patent literature
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Reviewing status
Peer reviewed