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Open Access Green as soon as Postprint is submitted to ZB.
Abundance of follicular helper T cells in Peyer's patches is modulated by CD155.
Eur. J. Immunol. 39, 3160-3170 (2009)
The secondary humoral immune response is characterized by plasma B cells secreting isotype-switched and affinity-matured antibodies. The efficient generation of plasma B cells in the GC depends on the presence of follicular helper T (T(FH)) cells, a cell type thought to arise from naive CD4-positive T cells by a hitherto unresolved differentiation pathway. Mice deficient for CD155, an adhesion receptor of the immunoglobulin superfamily, are impaired to mount a secondary humoral immune response upon oral administration of antigen, while the primary IgM response is unaffected. Here, we show that mice lacking CD155 harbor significantly reduced numbers of T(FH) cells in their Peyer's patches. This was paralleled by a decreased frequency of T(FH) cells in the GC. Moreover, the CD155 ligand CD226, which is involved in T-cell activation, is down-regulated during T(FH) cell differentiation, resulting in a complete absence of CD226 on those T(FH) cells residing in the GC. Concurrently, the expression of TIGIT/WUCAM, a newly discovered CD155 ligand, is induced in T(FH) cells. Thus, these cells replace an activating by a putative inhibitory CD155-binding partner during their differentiation.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
CD155; CD226; Follicular helper T cells; GC; TIGIT/WUCAM
ISSN (print) / ISBN
0014-2980
e-ISSN
1521-4141
Journal
European Journal of Immunology
Quellenangaben
Volume: 39,
Issue: 11,
Pages: 3160-3170
Publisher
Wiley
Publishing Place
Hoboken
Reviewing status
Peer reviewed
Institute(s)
Institute of Molecular Immunology (IMI)