Home
Deutsch
Advanced Search
Browse by ...
Publication overview
Contact persons
Help
DOI
PMC
 |
|
Open Access Green as soon as Postprint is submitted to ZB.
Chromosomal aberrations in thyroid follicular-cell neoplasia: In the search of novel oncogenes and tumour suppressor genes.
Mol. Cell. Endocrinol. 321, 57-66 (2010)
Thyroid cancer derived from the follicular cell is characterised by specific gene alterations that are closely linked to the various pathological types comprising papillary, follicular and anaplastic thyroid cancer. However, the correlation between molecular biology and pathology is not absolute, since about 30% of cases do not harbour the typical gene alterations. This situation, coupled with the demonstration of genetic heterogeneity in thyroid cancer, is a strong motivation for the search of novel gene alterations. Chromosomal aberrations are a good starting point to initiate this search and therefore the current knowledge on chromosomal alterations in thyroid follicular-cell neoplasia is reviewed in this article. An overview on molecular cytogenetic approaches for this strategy is also provided. The identification of novel genetic markers in thyroid cancer will be further improved by integrative approaches combining data from genomic and expression analyses with clinical data. This approach is powerful to identify genetic markers as well as new therapeutic targets in follicular-cell thyroid cancer.
Altmetric
Additional Metrics?
Edit extra informations
Login
Publication type
Article: Journal article
Document type
Review
Keywords
Follicular-cell neoplasia; Tumour suppressor gene; Oncogene; FISH; Chromosome; Rearrangement; Copy number alteration; Next-generation sequencing; Array CGH; Array painting
ISSN (print) / ISBN
0303-7207
e-ISSN
1872-8057
Quellenangaben
Volume: 321,
Issue: 1,
Pages: 57-66
Publisher
Elsevier
Publishing Place
Shannon
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Molecular Radiation Biology (IMS)