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Open Access Green as soon as Postprint is submitted to ZB.
Perspectives in understanding the role of human 17β-hydroxysteroid dehydrogenases in health and disease.
Ann. NY Acad. Sci. 1155, 15-24 (2009)
Steroid signaling involves specific receptors that mediate genomic effects and many further proteins responsible for fast nongenomic activities. Metabolism at the position 17 of the steroid scaffold plays a pivotal role in the final regulation of the biological potency of steroid hormones. Enzymes responsible for that, the 17beta-hydroxysteroid dehydrogenases (17beta-HSD), act as carbonyl reductases and require cofactors for their catalytic activity. There is a substantial amount of evidence that human 17beta-HSDs are as well involved in the metabolic pathways of retinoids and fatty acid beyond that which has so far been anticipated. At present fourteen 17beta-HSDs have been annotated and characterized, and more might follow. Many of 17beta-HSDs have been shown to be involved in the pathogenesis of human disorders and are targets for therapeutic intervention. Strategies on deciphering the physiological role of the 17beta-HSD and the genetic predisposition for associated diseases will be presented involving analyses of animal models.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
steroid metabolism; 17 beta-hydroxysteroid dehydrogenase (17 beta-HSD); human disorders; 17beta-hydroxy steroid dehydrogenases; short-chain dehydrogenases/reductases; prostaglandin-f synthase; pre-receptor regulation; breast-cancer; type-1 17-beta-hydroxy
ISSN (print) / ISBN
0077-8923
e-ISSN
1749-6632
Quellenangaben
Volume: 1155,
Issue: 2,
Pages: 15-24
Publisher
New York Academy of Sciences
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Molekulare Endokrinologie und Metabolismus (MEM)