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Open Access Green as soon as Postprint is submitted to ZB.
Perspectives in understanding the role of human 17β-hydroxysteroid dehydrogenases in health and disease.
Ann. NY Acad. Sci. 1155, 15-24 (2009)
Steroid signaling involves specific receptors that mediate genomic effects and many further proteins responsible for fast nongenomic activities. Metabolism at the position 17 of the steroid scaffold plays a pivotal role in the final regulation of the biological potency of steroid hormones. Enzymes responsible for that, the 17beta-hydroxysteroid dehydrogenases (17beta-HSD), act as carbonyl reductases and require cofactors for their catalytic activity. There is a substantial amount of evidence that human 17beta-HSDs are as well involved in the metabolic pathways of retinoids and fatty acid beyond that which has so far been anticipated. At present fourteen 17beta-HSDs have been annotated and characterized, and more might follow. Many of 17beta-HSDs have been shown to be involved in the pathogenesis of human disorders and are targets for therapeutic intervention. Strategies on deciphering the physiological role of the 17beta-HSD and the genetic predisposition for associated diseases will be presented involving analyses of animal models.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Times Cited
Scopus
Cited By
Cited By
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2.303
0.750
22
32
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
steroid metabolism; 17 beta-hydroxysteroid dehydrogenase (17 beta-HSD); human disorders; 17beta-hydroxy steroid dehydrogenases; short-chain dehydrogenases/reductases; prostaglandin-f synthase; pre-receptor regulation; breast-cancer; type-1 17-beta-hydroxy
Language
english
Publication Year
2009
HGF-reported in Year
2009
ISSN (print) / ISBN
0077-8923
e-ISSN
1749-6632
Quellenangaben
Volume: 1155,
Issue: 2,
Pages: 15-24
Publisher
New York Academy of Sciences
Reviewing status
Peer reviewed
Institute(s)
Molekulare Endokrinologie und Metabolismus (MEM)
POF-Topic(s)
30201 - Metabolic Health
Research field(s)
Genetics and Epidemiology
PSP Element(s)
G-505600-001
PubMed ID
19250188
Scopus ID
61649096847
Erfassungsdatum
2009-09-10