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Eussen, S.J.P.M.* ; Vollset, S.E.* ; Hustad, S.* ; Midttun, O.* ; Meyer, K.* ; Fredriksen, A.* ; Ueland, P.M.* ; Jenab, M.* ; Slimani, N.* ; Ferrari, P.* ; Agudo, A.* ; Sala, N.* ; Capella, G.* ; Del Giudice, G.* ; Palli, D.* ; Boeing, H.* ; Weikert, C.* ; Bueno-de-Mesquita, H.B.* ; Büchner, F.L.* ; Carneiro, F.* ; Berrino, F.* ; Vineis, P.* ; Tumino, R.* ; Panico, S.* ; Berglund, G.* ; Manjer, J.* ; Stenling, R.* ; Hallmans, G.* ; Martinez, C.* ; Arrizola, L.* ; Barricarte, A.* ; Navarro, C.* ; Rodriguez, L.* ; Bingham, S.* ; Linseisen, J. ; Kaaks, R.* ; Overvad, K.* ; Tjønneland, A.* ; Peeters, P.H.M.* ; Numans, M.E.* ; Clavel-Chapelon, F.* ; Boutron-Ruault, M.C.* ; Morois, S.* ; Trichopoulou, A.* ; Lund, E.* ; Plebani, M.* ; Riboli, E.* ; González, C.A.*

Vitamins B2 and B6 and genetic polymorphisms related to one-carbon metabolism as risk factors for gastric adenocarcinoma in the European prospective investigation into cancer and nutrition.

Cancer Epidemiol. Biomarkers Prev. 19, 28-38 (2010)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
B vitamins and polymorphisms in genes coding for enzymes involved in one-carbon metabolism may affect DNA synthesis and methylation and thereby be implicated in carcinogenesis. Previous data on vitamins B2 and B6 and genetic polymorphisms other than those involving MTHFR as risk factors for gastric cancer (GC) are sparse and inconsistent. In this case-control study nested within the European Prospective Investigation into Cancer and Nutrition cohort, cases (n = 235) and controls (n = 601) were matched for study center, age, sex, and time of blood sampling. B2 and B6 species were measured in plasma, and the sum of riboflavin and flavin mononucleotide was used as the main exposure variable for vitamin B2 status, whereas the sum of pyridoxal 5'-phosphate, pyridoxal, and 4-pyridoxic acid was used to define vitamin B6 status. In addition, we determined eight polymorphisms related to one-carbon metabolism. Relative risks for GC risk were calculated with conditional logistic regression, adjusted for Helicobacter pylori infection status and smoking status. Adjusted relative risks per quartile (95% confidence interval, P(trend)) were 0.85 (0.72-1.01, 0.06) for vitamin B2 and 0.78 (0.65-0.93, <0.01) for vitamin B6. Both relations were stronger in individuals with severe chronic atrophic gastritis. The polymorphisms were not associated with GC risk and did not modify the observed vitamin-cancer associations. In summary, results from this large European cohort study showed an inverse association between vitamin B2 and GC risk, which is borderline significant, and a significant inverse association between vitamin B6 and GC risk.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Helicobacter-pylori infection; Upper gastrointestinal-tract; Stomach-cancer; Methylenetetrahydrofolate-raductase; Nutrient intake; Homocysteine metabolism; MTHFR polymorphisms; Atrophic gastritis; Pernicious-anemia; Folate-deficiency
ISSN (print) / ISBN 1055-9965
e-ISSN 1538-7755
Journal Cancer Epidemiology, Biomarkers & Prevention
Quellenangaben Volume: 19, Issue: 1, Pages: 28-38 Article Number: , Supplement: ,
Publisher American Association for Cancer Research (AACR)
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)