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Open Access Green as soon as Postprint is submitted to ZB.
Comparison of fluorescence tomographic imaging in mice with early-arriving and quasi-continuous-wave photons.
Opt. Lett. 35, 369-371 (2010)
The highly diffuse nature of light propagation in biological tissue is a major challenge for obtaining high-fidelity fluorescence tomographic images. In this work we investigated the use of time-gated detection of early-arriving photons for reducing the effects of light scatter in mice relative to quasi-cw photons. When analyzing sinographic representations of the measured data, it was determined that early photons allowed a reduction in the measured FWHM of fluorescent targets by a factor of approximately 2-3, yielding a significant improvement in the tomographic image reconstruction quality.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Turbid media; Molecular tomography
ISSN (print) / ISBN
0146-9592
e-ISSN
1539-4794
Journal
Optics Letters
Quellenangaben
Volume: 35,
Issue: 3,
Pages: 369-371
Publisher
Optical Society of America (OSA)
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Biological and Medical Imaging (IBMI)