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Niedre, M.* ; Ntziachristos, V.

Comparison of fluorescence tomographic imaging in mice with early-arriving and quasi-continuous-wave photons.

Opt. Lett. 35, 369-371 (2010)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
The highly diffuse nature of light propagation in biological tissue is a major challenge for obtaining high-fidelity fluorescence tomographic images. In this work we investigated the use of time-gated detection of early-arriving photons for reducing the effects of light scatter in mice relative to quasi-cw photons. When analyzing sinographic representations of the measured data, it was determined that early photons allowed a reduction in the measured FWHM of fluorescent targets by a factor of approximately 2-3, yielding a significant improvement in the tomographic image reconstruction quality.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Turbid media; Molecular tomography
Language english
Publication Year 2010
HGF-reported in Year 2010
ISSN (print) / ISBN 0146-9592
e-ISSN 1539-4794
Journal Optics Letters
Quellenangaben Volume: 35, Issue: 3, Pages: 369-371 Article Number: , Supplement: ,
Publisher Optical Society of America (OSA)
Reviewing status Peer reviewed
POF-Topic(s) 30205 - Bioengineering and Digital Health
Research field(s) Enabling and Novel Technologies
PSP Element(s) G-505500-001
PubMed ID 20125724
Erfassungsdatum 2010-07-23