PuSH - Publication Server of Helmholtz Zentrum München: Diverse hematological malignancies including hodgkin-like lymphomas develop in chimeric MHC class II transgenic mice.

Navigation

Home

Deutsch

Research

Advanced Search

Browse by ...

... Journal

... Publication Type

... Research Data

... Publication Year

Publication overview

Support & Contact

Contact persons

Help

Data protection

Raffegerst, S.H. ; Hölzlwimmer, G. ; Kunder, S. ; Mysliwietz, J. ; Quintanilla-Martinez, L. ; Schendel, D.J.

Diverse hematological malignancies including hodgkin-like lymphomas develop in chimeric MHC class II transgenic mice.

PLoS ONE 4:e8539 (2009)

Publ. Version/Full Text Volltext

DOI

PMC

	Open Access Gold

Abstract
Metrics
Extra information

A chimeric HLA-DR4-H2-E (DR4) homozygous transgenic mouse line spontaneously develops diverse hematological malignancies with high frequency (70%). The majority of malignancies were distributed equally between T and B cell neoplasms and included lymphoblastic T cell lymphoma (LTCL), lymphoblastic B cell lymphoma (LBCL), diffuse large B cell lymphoma (DLBCL), the histiocyte/T cell rich variant of DLBCL (DLBCL-HA/T cell rich DLBCL), splenic marginal zone lymphoma (SMZL), follicular B cell lymphoma (FBL) and plasmacytoma (PCT). Most of these neoplasms were highly similar to human diseases. Also, some non-lymphoid malignancies such as acute myeloid leukemia (AML) and histiocytic sarcoma were found. Interestingly, composite lymphomas, including Hodgkin-like lymphomas, were also detected that had CD30(+) Hodgkin/Reed-Sternberg (H/RS)-like cells, representing a tumor type not previously described in mice. Analysis of microdissected H/RS-like cells revealed their origin as germinal center B cells bearing somatic hypermutations and, in some instances, crippled mutations, as described for human Hodgkin lymphoma (HL). Transgene integration in an oncogene was excluded as an exclusive driving force of tumorigenesis and age-related lymphoma development suggests a multi-step process. Thus, this DR4 line is a useful model to investigate common molecular mechanisms that may contribute to important neoplastic diseases in man.

Altmetric

Additional Metrics?

[➜Log in]

Edit extra informations Login

Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords COMBINED IMMUNODEFICIENT MICE; REED-STERNBERG CELLS; RECEPTOR BETA-CHAINS; CENTER B-CELLS; HEMATOPOIETIC NEOPLASMS; REARRANGEMENT ANALYSIS; BETHESDA PROPOSALS; DEFICIENT MICE; DISEASE; MODELS

ISSN (print) / ISBN 1932-6203

Journal PLoS ONE

Quellenangaben Volume: 4, Issue: 12, Article Number: e8539

Publisher Public Library of Science (PLoS)

Publishing Place Lawrence, Kan.

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Molecular Immunology (IMI)
CCG Immune Monitoring (Platform) (IMI-KIM)
Institute of Pathology (PATH)