PuSH - Publication Server of Helmholtz Zentrum München: Duffy antigen receptor for chemokines (Darc) polymorphism regulates circulating concentrations of monocyte chemoattractant protein-1 and other inflammatory mediators.

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Schnabel, R.B.* ; Baumert, J.J. ; Barbalic, M.* ; Dupuis, J.* ; Ellinor, P.T.* ; Durda, P.* ; Dehghan, A.* ; Bis, J.C.* ; Illig, T. ; Morrison, A.C.* ; Jenny, N.S.* ; Keaney, J.F.* ; Gieger, C. ; Tilley, C.* ; Yamamoto, J.F.* ; Khuseyinova, N.* ; Heiss, G.* ; Doyle, M.* ; Blankenberg, S.* ; Herder, C.* ; Walston, J.D.* ; Zhu, Y.Y.* ; Vasan, R.S.* ; Klopp, N. ; Boerwinkle, E.* ; Larson, M.G.* ; Psaty, B.M.* ; Peters, A. ; Ballantyne, C.M.* ; Witteman, J.C.M.* ; Hoogeveen, R.C.* ; Benjamin, E.J.* ; Koenig, W.* ; Tracy, R.P.*

Duffy antigen receptor for chemokines (Darc) polymorphism regulates circulating concentrations of monocyte chemoattractant protein-1 and other inflammatory mediators.

Blood 115, 5289-5299 (2010)

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To identify the genetic basis of circulating concentrations of monocyte chemoattractant protein-1 (MCP-1), we conducted genome-wide association analyses for MCP-1 in 3 independent cohorts (n = 9598). The strongest association was for serum MCP-1 with a nonsynonymous polymorphism, rs12075 (Asp42Gly) in DARC, the gene for Duffy antigen receptor for chemokines, a known vascular reservoir of proinflammatory cytokines (minor allele frequency, 45.6%; P < 1.0 * 10(-323)). This association was supported by family-based genetic linkage at a locus encompassing the DARC gene (genome-wide P = 8.0 * 10(-13)). Asp42Gly accounted for approximately 20% of the variability in serum MCP-1 concentrations and also was associated with serum concentrations of interleukin-8 and RANTES. While exploring a lack of association between this polymorphism and EDTA plasma MCP-1 concentrations (P = .82), we determined that both clotting and exogenous heparan sulfate (unfractionated heparin) released substantial amounts of MCP-1 from Darc. Quantitative immunoflow cytometry failed to identify meaningful Asp42Gly-associated differences in Darc expression, suggesting that a functional change is responsible for the differential cytokine binding. We conclude that Asp42Gly is a major regulator of erythrocyte Darc-mediated cytokine binding and thereby the circulating concentrations of several proinflammatory cytokines. We have also identified for the first time 2 mechanisms for the release of reservoir chemokines with possible clinical implications.

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