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Open Access Gold as soon as Publ. Version/Full Text is submitted to ZB.
Genome-associated RNA polymerase II includes the dissociable Rpb4/7 subcomplex.
J. Biol. Chem. 283, 26423-26427 (2008)
Yeast RNA polymerase (Pol) II consists of a 10-subunit core enzyme and the Rpb4/7 subcomplex, which is dispensable for catalytic activity and dissociates in vitro. To investigate whether Rpb4/7 is an integral part of DNA-associated Pol II in vivo, we used chromatin immunoprecipitation coupled to high resolution tiling microarray analysis. We show that the genome-wide occupancy profiles for Rpb7 and the core subunit Rpb3 are essentially identical. Thus, the complete Pol II associates with DNA in vivo, consistent with functional roles of Rpb4/7 throughout the transcription cycle.
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Publication type
Article: Journal article
Document type
Scientific Article
ISSN (print) / ISBN
0021-9258
e-ISSN
1083-351X
Quellenangaben
Volume: 283,
Issue: 39,
Pages: 26423-26427
Publisher
American Society for Biochemistry and Molecular Biology
Reviewing status
Peer reviewed
Institute(s)
Institute of Molecular Immunology (IMI)