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Schmahl, W. ; Funk, R. ; Miaskowski, U. ; Plendl, J.

Long-lasting Effects of Naltrexone, an Opioid Receptor Antagonist, on Cell Proliferation in Developing Rat Forebrain.

Brain Res. 486, 297-300 (1989)
DOI
Open Access Green as soon as Postprint is submitted to ZB.
Several studies have demonstrated in the past that endogenous opioid peptides and opioid receptors may be involved as mediators of brain tissue growth and function in the neonate. Applying histological and autoradiographic methods, we have examined the effect of the μ-receptor-specific antagonist, naltrexone, on the proliferation of the 4–12-week-old rat forebrain subependymal layer. We found that naltrexone, when given daily throughout the weaning period, evoked a long-lasting increase of the mitotic rate and the [3H]thymidine labelling index. This effect was most significant about 8–10 weeks after ending the naltrexone treatment. Although a direct influence of naltrexone on long-term subependymal cell proliferation cannot be excluded, we are discussing evidence of an indirect effect via suppression of noradrenergic activity in the forebrain.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Naltrexone; Rat brain; Cell proliferation
Language english
Publication Year 1989
HGF-reported in Year 0
ISSN (print) / ISBN 0006-8993
e-ISSN 1872-6240
Journal Brain Research
Quellenangaben Volume: 486, Issue: 2, Pages: 297-300 Article Number: , Supplement: ,
Publisher Elsevier
Reviewing status Peer reviewed
Institute(s) Institute of Pathology (PATH)
DOI 10.1016/0006-8993(89)90515-5
Erfassungsdatum 1989-12-31
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