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Open Access Green as soon as Postprint is submitted to ZB.
Mouse Bone Marrow-Derived IL-3-dependent Mast Cells and Autonomous Sublines Produce IL-6.
Immunology 67, 408-413 (1989)
This study deals with the question of whether mouse bone marrow-derived mast cells are able to produce interleukin-6 (IL-6) in vitro. For this purpose, a panel of primary mast cell clones from limiting-dilution microcultures, of permanent IL-3-dependent mast cell lines and autonomous malignant sublines, was screened. All of these lines were found to produce growth factor activity for IL-6-dependent mouse hybridoma cells (7TD1), which could be completely neutralized by the monoclonal anti-IL-6-antibody 6B4. Transcriptional activity of the IL-6 gene was demonstrated in both IL-3-dependent mast cells and autonomous sublines using a mouse IL-6-specific cDNA probe.
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Publication type
Article: Journal article
Document type
Scientific Article
ISSN (print) / ISBN
0019-2805
e-ISSN
1365-2567
Journal
Immunology
Quellenangaben
Volume: 67,
Issue: 3,
Pages: 408-413
Publisher
Wiley
Non-patent literature
Publications
Reviewing status
Peer reviewed