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Open Access Gold as soon as Publ. Version/Full Text is submitted to ZB.
Early Plasma Cell Recruitment in Multiple Myeloma Following Chemotherapy.
Cell Prolif. 21, 405-409 (1988)
Therapy-induced modifications of bone marrow plasma cell kinetics were studied in three patients with myelomatosis. The investigation was performed prior to and 15 d after termination of a course of aggressive chemotherapy. An increase in the labelling index (40-212% of pretreatment values) with a corresponding reduction of Ts (5-34%) was observed in all cases. As a consequence of this combined variation, the fractional turnover rate (which represents the percentage of cells produced per unit time) was the parameter with the highest increment (54-276%). These results indicate that plasma cell recruitment occurs soon after chemotherapy and is characterized by a shorter S phase and a higher number of DNA-synthesizing cells.
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Publication type
Article: Journal article
Document type
Scientific Article
ISSN (print) / ISBN
0008-8730
e-ISSN
1365-2184
Journal
Cell Proliferation
Quellenangaben
Volume: 21,
Issue: 6,
Pages: 405-409
Publisher
Blackwell
Publishing Place
Oxford [u.a.] ; Berlin ; Vienna
Non-patent literature
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Reviewing status
Peer reviewed