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Open Access Green as soon as Postprint is submitted to ZB.
A Case of Malignant Mastocytosis with Near-haploid, Near-Duiploid and Polyploid Cells in the Bone Marrow.
Cancer Genet. Cytogenet. 48, 13-21 (1990)
Chromosome analysis in bone marrow cells of a 41-year-old woman with malignant mastocytosis (MM) revealed near-haploid (59%), near-diploid (36%), and polyploid (5%) cells. Near-haploid cells had a mode of 25 chromosomes with variable disomy and nullisomy of particular chromosomes. Disomy for chromosome 19 and chromosome 20 were most common. A 17p + marker was observed in all cells. Other structural chromosomal changes were dicentrics, ring chromosomes, translocations, and double minutes. The modal chromosome number in near-diploid cells was 46 with a range of 41–52. The majority of cells with 46 chromosomes were pseudodiploid and only a few had a normal female karyotype. As in near-haploid cells, various structural chromosomal changes were found. The 17p + marker was also present in occasional cells suggesting a relationship between the two tumor cell populations. Chromosome numbers in polyploid cells ranged from 70 to about 600. Identical copies of dicentrics or markers were identified in some cells.
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Publication type
Article: Journal article
Document type
Scientific Article
ISSN (print) / ISBN
0165-4608
e-ISSN
1873-4456
Journal
Cancer Genetics and Cytogenetics
Quellenangaben
Volume: 48,
Issue: 1,
Pages: 13-21
Publisher
Elsevier
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Radiation Biology (ISB)