PuSH - Publication Server of Helmholtz Zentrum München

Kerler, F. ; Hültner, L. ; Ziegler, I. ; Katzenmaier, G. ; Bacher, A.

Analysis of the Tetrahydrobiopterin Synthesizing System During Maturation of Murine Reticulocytes.

J. Cell. Physiol. 142, 268-271 (1990)
PMC
Open Access Green as soon as Postprint is submitted to ZB.
The enzymes of tetrahydrobiopterin synthesis have been studied in murine bone marrow, in spleen, in erythrocytes, and in reticulocytes. Mice with chemically induced and with genetically conditioned reticulocytosis as found in the lactate dehydrogenase deficient strain (Ldh-1c/Ldh-1c) were used for analysis of reticulocytic enzyme activities. The activity of the biopterin synthesizing system is highest in bone marrow even though it amounts to only about 10% as compared with liver. The first enzyme of the biosynthetic pathway, GTP-cyclohydrolase, virtually disappears during the final maturation step of reticulocytes. In contrast, the activities of 6-pyruvoyltetrahydropterin synthase and of sepiapterin reductase of erythrocytes are only reduced to about one half of the reticulocyte level. The absence of biopterin in erythrocytes is therefore caused by the loss of the enzyme that initiates the pterin biosynthetic pathway.
Altmetric
Additional Metrics?
[➜Log in]
Edit extra informations Login
Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
ISSN (print) / ISBN 0021-9541
e-ISSN 1097-4652
Journal Journal of Cellular Physiology
Quellenangaben Volume: 142, Issue: 2, Pages: 268-271 Article Number: , Supplement: ,
Publisher Wiley
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Clinical Molecular Biology and Tumor Genetics (K.MOLBI)