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Open Access Green as soon as Postprint is submitted to ZB.
2-Nitropropane induced DNA Repair Synthesis in Rat Hepatocytes in Vitro and in Vivo.
Carcinogenesis 9, 811-815 (1989)
The genotoxicity of 2-nitropropane (2-NP) and 1-nitropropane (1-NP) was investigated by measuring the induction of DNA repair synthesis in rat liver cells in vitro and in vivo. 2-NP strongly induced DNA repair synthesis in both cases. When applied in vivo, 2-NP was considerably more effective in hepatocytes from males than in those from females. 1-NP was not active in vitro or in vivo. 2-NP and 1-NP did not induce repair in cell lines of extrahepatic origin derived from rat, mouse, hamster and man. The results are consistent with the reported carcinogenicity of 2-NP in rat liver and suggest that the formation of hepatocarcinomas by 2-NP is due to the generation of a genotoxic metabolite from 2-NP by liver-specific metabolism.
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Publication type
Article: Journal article
Document type
Scientific Article
ISSN (print) / ISBN
0143-3334
e-ISSN
1460-2180
Journal
Carcinogenesis
Quellenangaben
Volume: 9,
Issue: 5,
Pages: 811-815
Publisher
Oxford University Press
Reviewing status
Peer reviewed