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Pinto, L. ; Mader, M.T. ; Irmler, M. ; Gentilini, M.* ; Santoni, F.* ; Drechsel, D. ; Blum, R.* ; Stahl, R.* ; Bulfone, A.* ; Malatesta, P.* ; Beckers, J. ; Götz, M.

Prospective isolation of functionally distinct radial glial subtypes--lineage and transcriptome analysis.

Mol. Cell. Neurosci. 38, 15-42 (2008)
DOI
Open Access Green as soon as Postprint is submitted to ZB.
Since the discovery of radial glia as the source of neurons, their heterogeneity in regard to neurogenesis has been described by clonal and time-lapse analysis in vitro. However, the molecular determinants specifying neurogenic radial glia differently from radial glia that mostly self-renew remain ill-defined. Here, we isolated two radial glial subsets that co-exist at mid-neurogenesis in the developing cerebral cortex and their immediate progeny. While one subset generates neurons directly, the other is largely non-neurogenic but also gives rise to Tbr2-positive basal precursors, thereby contributing indirectly to neurogenesis. Isolation of these distinct radial glia subtypes allowed determining interesting differences in their transcriptome. These transcriptomes were also strikingly different from the transcriptome of radial glia isolated at the end of neurogenesis. This analysis therefore identifies, for the first time, the lineage origin of basal progenitors and the molecular differences of this lineage in comparison to directly neurogenic and gliogenic radial glia.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Neurogenesis; Gliogenesis; Development; Cerebral cortex; Radial glia; Basal precursors; Lineage; Transcriptome; Pax6; Oligodendrogenesis
Language
Publication Year 2008
HGF-reported in Year 2008
ISSN (print) / ISBN 1044-7431
e-ISSN 1095-9327
Journal Molecular and Cellular Neuroscience
Quellenangaben Volume: 38, Issue: 1, Pages: 15-42 Article Number: , Supplement: ,
Publisher Elsevier
Reviewing status Peer reviewed
Institute(s) Institute of Stem Cell Research (ISF)
Institute of Experimental Genetics (IEG)
POF-Topic(s) 30204 - Cell Programming and Repair
30201 - Metabolic Health
Research field(s) Stem Cell and Neuroscience
Genetics and Epidemiology
PSP Element(s) G-500800-001
G-500600-004
DOI 10.1016/j.mcn.2008.01.012
Scopus ID 43049119575
Erfassungsdatum 2008-08-26
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