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Open Access Green as soon as Postprint is submitted to ZB.
Nuclear Breakdown During Terminal Differentiation of Primary Lens Fibers in Mice.
Exp. Eye Res. 52, 647-659 (1990)
The pre and post-natal development of wild type mouse lenses was studied by transmission electron microscopy, with special emphasis on denucleation of primary lens fibres. Denucleation of primary fibres is characterized by nuclear accumulation of small granules, most likely nucleosomes, which are condensed to osmiophilic bodies in the nucleus and in the cytoplasm. The osmiophilic bodies are laid down in apposition to the fibre membrane and are invaded by vesicles and granules, which probably contain proteolytic enzymes. Part of the breakdown products are extruded into the extracellular space, transported to the anterior and posterior poles where they might be finally digested or discarded from the lens. The morphology of the denucleation process of primary fibres is different from the gradual fading of nuclei in secondary fibres as described by Kuwabara and Imaizumi (1974: Invest. Ophthalmol. Vis. Sci. 13, 973-81).
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
crystallin lens; embryogenesis; denucleation; mouse; electron microscopy
ISSN (print) / ISBN
0014-4835
e-ISSN
1096-0007
Journal
Experimental Eye Research
Quellenangaben
Volume: 52,
Issue: 6,
Pages: 647-659
Publisher
Elsevier
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Developmental Genetics (IDG)