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Winkler, C. ; Illig, T. ; Koczwara, K. ; Bonifacio, E.* ; Ziegler, A.-G.

HHEX-IDE polymorphism is associated with low birth weight in offspring with a family history of type 1 diabetes.

J. Clin. Endocrinol. Metab. 94, 4113-4115 (2009)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
The fetal insulin hypothesis proposes that common genetic variants that reduce insulin secretion also reduce birth weight, and an association of low birth weight and the type 2 diabetes risk alleles at the HHEX-IDE and CDKAL1 loci were recently reported. OBJECTIVE: Here, we examined the relationship between type 2 diabetes risk alleles and birth weight in a diabetic environment presented in children of mothers with type 1 diabetes. RESEARCH DESIGN AND METHODS: Birth weight and genotyping of single nucleotide polymorphisms (SNPs) at the CDKAL1, HHEX-IDE, and SLC30A8 loci was obtained and analyzed in 729 singleton full-term children of mothers with type 1 diabetes born in Germany. RESULTS: The fetal risk alleles of HHEX-IDE SNP rs5015480 and SNP rs10882102 were associated with reduced birth weight: 81g (95% confidence interval, 20-140 g; P = 0.009) and 85 g (95% confidence interval, 25-145 g; P = 0.005) lower birth weight per risk allele, respectively. The association remained significant after adjusting for maternal pregnancy-glycosylated hemoglobin. Fetal genotypes at the CDKAL1 and SLC30A8 loci were not associated with birth weight in this cohort. CONCLUSIONS: The association of low birth weight and type 2 diabetes risk alleles of the HHEX-IDE locus is confirmed in children of mothers with type 1 diabetes.
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Publication type Article: Journal article
Document type Scientific Article
Keywords fetal-growth; insulin; appearance; risk
ISSN (print) / ISBN 0021-972X
e-ISSN 1945-7197
Journal Journal of Clinical Endocrinology & Metabolism, The
Quellenangaben Volume: 94, Issue: 10, Pages: 4113-4115 Article Number: , Supplement: ,
Publisher Endocrine Society
Publishing Place Bethesda, Md.
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes Research (IDF)
Institute of Epidemiology (EPI)
Institute of Pancreatic Islet Research (IPI)