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Open Access Green as soon as Postprint is submitted to ZB.
Transcriptional Down-regulation of c-myc in Human Prostate Carcinoma Cells by the Synthetic Androgen Mibolerone.
Br. J. Cancer 65, 376-382 (1992)
The mechanism of down-regulation of c-myc RNA associated with androgen-induced suppression of the transformed phenotype in the human prostate carcinoma cell line LNCaP was investigated. The synthetic androgen mibolerone (7 alpha-17 alpha-Dimethyl-19-nortestosterone) reversibly inhibits the proliferation of LNCaP cells and, from 12-72 h after hormone addition reduces the level of c-myc transcripts to a few per cent of controls. P1, P2, and P0 c-myc transcripts decline at the same rate, whereas P3 transcripts are much less hormone sensitive. Nuclear run-on analysis revealed that c-myc is down-regulated at the level of transcription initiation in LNCaP cells. The level of c-myc transcripts prevailing in untreated control cells can be restored in androgen-induced cells by excess antiandrogen, indicating the involvement of the androgen receptor in c-myc down-regulation.
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Publication type
Article: Journal article
Document type
Scientific Article
ISSN (print) / ISBN
0007-0920
e-ISSN
1532-1827
Journal
British Journal of Cancer BJC
Quellenangaben
Volume: 65,
Issue: 3,
Pages: 376-382
Publisher
Nature Publishing Group
Non-patent literature
Publications
Reviewing status
Peer reviewed