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MitoP2: The mitochondrial proteome database-now including mouse data.
Nucleic Acids Res. 34, D705-D711 (2006)
The MitoP2 database (http://www.mitop.de) integrates information on mitochondrial proteins, their molecular functions and associated diseases. The central database features are manually annotated reference proteins localized or functionally associated with mitochondria supplied for yeast, human and mouse. MitoP2 enables (i) the identification of putative orthologous proteins between these species to study evolutionarily conserved functions and pathways; (ii) the integration of data from systematic genome-wide studies such as proteomics and deletion phenotype screening; (iii) the prediction of novel mitochondrial proteins using data integration and the assignment of evidence scores; and (iv) systematic searches that aim to find the genes that underlie common and rare mitochondrial diseases. The data and analysis files are referenced to data sources in PubMed and other online databases and can be easily downloaded. MitoP2 users can explore the relationship between mitochondrial dysfunctions and disease and utilize this information to conduct systems biology approaches on mitochondria.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
C-OXIDASE DEFICIENCY; SACCHAROMYCES-CEREVISIAE; GLOBAL ANALYSIS; YEAST; PROTEINS; GENOME; EXPRESSION; SCALE; IDENTIFICATION; KNOWLEDGEBASE
ISSN (print) / ISBN
0305-1048
e-ISSN
1362-4962
Journal
Nucleic Acids Research
Quellenangaben
Volume: 34,
Issue: SI,
Pages: D705-D711
Publisher
Oxford University Press
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Peer reviewed