PuSH - Publication Server of Helmholtz Zentrum München: Are Serotonergic Mechanisms Involved in the Acute Toxicity of Chlorinated Dibenzo-p-dioxins ( CDDs)?.

Information

Clues to quality of journals

Open Access Policy of Helmholtz Association 2016

CC Licencences

Publication Metrics

Navigation

Home

Deutsch

EVA: Electronic Publishing

New EVA Application

Research

Advanced Search

Browse by ...

... HMGU-Authors/Consortia

... Organizational Structure

... Journal

... Publication Type

... Research Data

... Arbeitsgruppen

... Publication Year

Publication overview

Statistics

Statistics (last 5 years)

OA Publications

Publish

Submit Publication

Import publication from...

...EVA

Report missing publication

Highlights

Support & Contact

Contact persons

Help

Data protection

Helmholtz Open Science

JANE Journal Estimator

SHERPA/RoMEO

DOAJ

Export:

Text

Endnote (RIS) BIB

BibTeX

Weber, L.W.D. ; Stahl, B.U. ; Rozman, K.K.

Are Serotonergic Mechanisms Involved in the Acute Toxicity of Chlorinated Dibenzo-p-dioxins ( CDDs)?.

Chemosphere 25, 161-164 (1992)

DOI

Open Access Gold as soon as Publ. Version/Full Text is submitted to ZB.

Abstract
Metrics
Extra information

The mechanism of CDD-induced appetite suppression was studied in male Sprague-Dawley rats. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) served as the model compound; additional experiments were performed using higher chlorinated CDDs (penta-, hexa-, hepta-, and a mixture) with substituents in the biologically crucial 2-, 3-, 7-, and 8-positions. All homologues, plus their equipotent mixture, led to an increase of plasma and brain tryptophan (TRP) levels and concomitantly serotonin (5-HT) turnover, in the very same dose range where acute toxicity occurred. The reason for elevated TRP levels was an inhibition of the activity of tryptophan 2,3-dioxygenase (TdO) in the livers of treated animals. A direct effect of TCDD on the central nervous system (CNS) was ruled out. Depletion of CNS 5-HT stores by administration of 5,7-dihydroxytryptamine (5,7-dHT) did not influence the TCDD-induced appetite suppression, and thus it was concluded that 5-HT causes aphagia by a peripheral mechanism. Based on the similarity of symptoms caused by CDDs on the one hand, and tumor necrosis factor (TNF) on the other hand, a mechanism of action is proposed where CDDs render the organism non-responsive to glucocorticoid receptor-mediated stimuli, locking the activities of several key enzymes of intermediary metabolism to low levels which do not allow the organism to respond appropriately to appetite suppression and hypoglycemia.

Impact Factor

Scopus SNIP

Scopus
Cited By

Altmetric

0.000

PuSH - Publication Server of Helmholtz Zentrum München

Are Serotonergic Mechanisms Involved in the Acute Toxicity of Chlorinated Dibenzo-p-dioxins ( CDDs)?.

Are Serotonergic Mechanisms Involved in the Acute Toxicity of Chlorinated Dibenzo-p-dioxins ( CDDs)?.