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Do Infections Induce Monoclonal Immunoglobulin Components?.
Clin. Exp. Immunol. 81, 435-440 (1990)
The incidenlal finding of monocional immunoglobuiin components (MC) in some infections prompted us lo study this phenomenon more systematically. Using isoelectric focusing withimmunoblotting {detection limit for MC O'l mg/ml), the following infections were studied for thepresence of MC: visceral leishmaniasis, cytomcgalovirus (CMV) infection, echinococcosis andinfectious mononucleosis. MC were found in 16 of 20 leishmania patients and in eight of 18 CMV patients, but in only one of 20 echinococcosis patients and in none of 30 infectious mononucleosispatients. The MC were mostly transient, where tested. A minority of the MC found in theleishmaniasis patients was shown to bind to leishmania antigens. The specificity ofthe majority ofthe MC remains unknown. Further study is required to explain the high incidence of MC in CMV infection and visceral leishmaniasis.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
monoclonal immunoglobulin components visceral leishmaniasis cytomegalovirus
mononucleosis
Language
english
Publication Year
1990
HGF-reported in Year
0
ISSN (print) / ISBN
0009-9104
e-ISSN
1365-2249
Quellenangaben
Volume: 81,
Pages: 435-440
Publisher
Wiley
Reviewing status
Peer reviewed
Erfassungsdatum
1990-12-31