PuSH - Publication Server of Helmholtz Zentrum München: The Terminal Protein Gene 2 of Epstein-Barr Virus Is Transcribed from a Bidirectional Latent Promoter Region.

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Laux, G. ; Economou, A. ; Farrell, P.J.

The Terminal Protein Gene 2 of Epstein-Barr Virus Is Transcribed from a Bidirectional Latent Promoter Region.

J. Gen. Virol. 70, 3079-3084 (1989)

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The intact terminal protein genes (TP1 and TP2) of Epstein-Barr virus (EBV) are created upon infection by circularization of the linear viral genome at its terminal repeats. The structure of the 1 7 kb TP2 latent mRNA has been determined by cDNA analysis and Northern blotting, revealing its close relation to TP1 MRNA. The 1 7 kb transcript is expressed from a different promoter and has a different 5´exon from TP1 but is also spliced across the terminal repeats. The last eight exons are common to the TP1 and TP2 RNAs. The TP2 promoter is 3 3 kb downstream of the TP1 promoter and is part of a bidirectional latent EBV promoter region transcribing the TP2 and the latent membrane protein RNAs in opposite directions.

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