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Open Access Green as soon as Postprint is submitted to ZB.
Genetic variation in the lymphotoxin-alpha pathway and the risk of ischemic stroke in European populations.
Stroke 40, 970-972 (2009)
Several genes involved in the lymphotoxin-alpha cascade (LTA, LGALS2, and PSMA6) have been linked with the risk of myocardial infarction. Here, we present a comprehensive analysis of these genes in patients with ischemic stroke (IS). METHODS: Twenty-three single nucleotide polymorphisms (SNPs) from LTA, LGALS2, and PSMA6 were genotyped in 601 German IS patients and 736 matched controls. SNPs and haplotypes were tested for association with overall IS, large vessel stroke, and cardioembolic stroke. Significant associations were replicated in an independent sample of 843 IS cases and 933 controls from the UK. RESULTS: Only one SNP (rs1048990 in PSMA6) showed association with overall IS, but this was not replicated in the UK sample. Three SNPs showed significant associations with stroke subtypes (P<0.05), but none of these associations could be replicated in the UK population. CONCLUSIONS: Genetic variation in the lymphotoxin-alpha cascade (LTA, LGALS2, and PSMA6) is not a major risk factor for IS.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
stroke; genetics; PSMA6; LTA; LGALS2
Language
english
Publication Year
2009
HGF-reported in Year
0
ISSN (print) / ISBN
0039-2499
e-ISSN
1524-4628
Journal
Stroke
Quellenangaben
Volume: 40,
Issue: 3,
Pages: 970-972
Publisher
Lippincott Williams & Wilkins
Publishing Place
United States
Reviewing status
Peer reviewed
Institute(s)
Institute of Human Genetics (IHG)
Institute of Epidemiology (EPI)
Institute of Epidemiology (EPI)
POF-Topic(s)
30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
30503 - Chronic Diseases of the Lung and Allergies
30503 - Chronic Diseases of the Lung and Allergies
Research field(s)
Genetics and Epidemiology
PSP Element(s)
G-500700-001
G-503900-001
G-503900-001
PubMed ID
19182073
Erfassungsdatum
2009-11-27