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Bartholomäus, I.* ; Kawakami, N.* ; Odoardi, F.* ; Schläger, C.* ; Miljkovic, D.* ; Ellwart, J.W. ; Klinkert, W.E.* ; Flügel-Koch, C.* ; Issekutz, T.B.* ; Wekerle, H.* ; Flügel, A.*

Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesions.

Nature 462, 94-98 (2009)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
The tissues of the central nervous system are effectively shielded from the blood circulation by specialized vessels that are impermeable not only to cells, but also to most macromolecules circulating in the blood. Despite this seemingly absolute seclusion, central nervous system tissues are subject to immune surveillance and are vulnerable to autoimmune attacks. Using intravital two-photon imaging in a Lewis rat model of experimental autoimmune encephalomyelitis, here we present in real-time the interactive processes between effector T cells and cerebral structures from their first arrival to manifest autoimmune disease. We observed that incoming effector T cells successively scanned three planes. The T cells got arrested to leptomeningeal vessels and immediately monitored the luminal surface, crawling preferentially against the blood flow. After diapedesis, the cells continued their scan on the abluminal vascular surface and the underlying leptomeningeal (pial) membrane. There, the T cells encountered phagocytes that effectively present antigens, foreign as well as myelin proteins. These contacts stimulated the effector T cells to produce pro-inflammatory mediators, and provided a trigger to tissue invasion and the formation of inflammatory infiltrations.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords experimental allergic encephalomyelitis; cental-nervous-system; germline transmission; dendritic cells; choroid-plexus; antigen; protein; lymphocytes; brain; extravasation
ISSN (print) / ISBN 0028-0836
e-ISSN 1476-4687
Journal Nature
Quellenangaben Volume: 462, Issue: 7269, Pages: 94-98 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Publishing Place London
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Molecular Immunology (IMI)