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Open Access Green as soon as Postprint is submitted to ZB.
Genetics of sleep and sleep disorders.
Cell. Mol. Life Sci. 64, 1216-1226 (2007)
Genetic factors affect sleep. Studies in twin pairs demonstrate that the strong hereditary influences on sleep architecture and some sleep disorders are transmitted through families. Evidence like this strongly suggests that sleep regulation receives significant influence from genetic factors. Although recent molecular technologies have revealed evidence that genetic traits or gene products trigger particular changes in sleep electroencephalogram activity, we are still far from finding candidate genes or multiple mutations responsible for individual sleep disorders. Sleep is a very complex phenotype. Genetic susceptibility and environmental factors should be also considered as contributors to sleep phenotype. The aim of this review is to present a current summary and future prospects for genetic studies on sleep and selected sleep-associated disorders.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Chromosome; familial sleep disorders; electroencephalography (EEG); genotype; heritability; inbread mice; mutations; polymorphism
ISSN (print) / ISBN
1420-682X
e-ISSN
1420-9071
Quellenangaben
Volume: 64,
Issue: 10,
Pages: 1216-1226
Publisher
Birkhäuser
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Human Genetics (IHG)