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Kimura, M.* ; Winkelmann, J.

Genetics of sleep and sleep disorders.

Cell. Mol. Life Sci. 64, 1216-1226 (2007)
DOI
Open Access Green as soon as Postprint is submitted to ZB.
Genetic factors affect sleep. Studies in twin pairs demonstrate that the strong hereditary influences on sleep architecture and some sleep disorders are transmitted through families. Evidence like this strongly suggests that sleep regulation receives significant influence from genetic factors. Although recent molecular technologies have revealed evidence that genetic traits or gene products trigger particular changes in sleep electroencephalogram activity, we are still far from finding candidate genes or multiple mutations responsible for individual sleep disorders. Sleep is a very complex phenotype. Genetic susceptibility and environmental factors should be also considered as contributors to sleep phenotype. The aim of this review is to present a current summary and future prospects for genetic studies on sleep and selected sleep-associated disorders.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Chromosome; familial sleep disorders; electroencephalography (EEG); genotype; heritability; inbread mice; mutations; polymorphism
ISSN (print) / ISBN 1420-682X
e-ISSN 1420-9071
Quellenangaben Volume: 64, Issue: 10, Pages: 1216-1226 Article Number: , Supplement: ,
Publisher Birkhäuser
Non-patent literature Publications
Reviewing status Peer reviewed