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Open Access Green as soon as Postprint is submitted to ZB.
A Dlx2- and Pax6-dependent transcriptional code for periglomerular neuron specification in the adult olfactory bulb.
J. Neurosci. 28, 6439-6452 (2008)
Distinct olfactory bulb (OB) interneurons are thought to become specified depending on from which of the different subregions lining the lateral ventricle wall they originate, but the role of region-specific transcription factors (TFs) in the generation of OB interneurons diversity is still poorly understood. Despite the crucial roles of the Dlx family of TFs for patterning and neurogenesis in the ventral telencephalon during embryonic development, their role in adult neurogenesis has not yet been addressed. Here we show that in the adult brain, Dlx 1 and Dlx2 are expressed in progenitors of the lateral but not the dorsal subependymal zone (SEZ), thus exhibiting a striking regional specificity. Using retroviral vectors to examine the function of Dlx2 in a cell-autonomous manner, we demonstrate that this TF is necessary for neurogenesis of virtually all OB interneurons arising from the lateral SEZ. Beyond its function in generic neurogenesis, Dlx2 also plays a crucial role in neuronal subtype specification in the OB, promoting specification of adult-born periglomerular neurons (PGNs) toward a dopaminergic fate. Strikingly, Dlx2 requires interaction with Pax6, because Pax6 deletion blocks Dlx2-mediated PGN specification. Thus, Dlx2 wields a dual function by first instructing generic neurogenesis from adult precursors and subsequently specifying PGN subtypes in conjunction with Pax6.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
neurogenesis; subependymal zone; olfactory bulb; transcription factor; tyrosine hydroxylase; stem cell
ISSN (print) / ISBN
0270-6474
e-ISSN
1529-2401
Journal
Journal of Neuroscience
Quellenangaben
Volume: 28,
Issue: 25,
Pages: 6439-6452
Publisher
Society for Neuroscience
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Stem Cell Research (ISF)