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Open Access Gold as soon as Publ. Version/Full Text is submitted to ZB.
dMec: A novel Mi-2 chromatin remodelling complex involved in transcriptional repression.
EMBO J. 28, 533-544 (2009)
The ATP-dependent chromatin remodeller Mi-2 functions as a transcriptional repressor and contributes to the suppression of cell fates during development in several model organisms. Mi-2 is the ATPase subunit of the conserved Nucleosome Remodeling and Deacetylation (NuRD) complex, and transcriptional repression by Mi-2 is thought to be dependent on its associated histone deacetylase. Here, we have purified a novel dMi-2 complex from Drosophila that is distinct from dNuRD. dMec (dMEP-1 complex) is composed of dMi-2 and dMEP-1. dMec is a nucleosome-stimulated ATPase that is expressed in embryos, larval tissues and adult flies. Surprisingly, dMec is far more abundant than dNuRD and constitutes the major dMi-2-containing complex. Both dNuRD and dMec associate with proneural genes of the achaete-scute complex. However, despite lacking a histone deacetylase subunit, only dMec contributes to the repression of proneural genes. These results reveal an unexpected complexity in the composition and function of Mi-2 complexes.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
ATP-dependent chromatin remodelling; dMEP-1; Mi-2; NuRD; transcription; histone deacetylase; nurd complex; cell fate; drosophila; binding; protein; dmi-2; mi-2/nurd; mta3; dermatomyositis
ISSN (print) / ISBN
0261-4189
e-ISSN
1460-2075
Journal
EMBO Journal, The
Quellenangaben
Volume: 28,
Issue: 5,
Pages: 533-544
Publisher
Wiley
Publishing Place
Heidelberg, Germany
Reviewing status
Peer reviewed
Institute(s)
Institute of Molecular Immunology (IMI)