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Open Access Green as soon as Postprint is submitted to ZB.
Hematopoietic cytokines can instruct lineage choice.
Science 325, 217-218 (2009)
The constant regeneration of the blood system during hematopoiesis requires tightly controlled lineage decisions of hematopoietic progenitor cells (HPCs). Because of technical limitations, differentiation of individual HPCs could not previously be analyzed continuously. It was therefore disputed whether cell-extrinsic cytokines can instruct HPC lineage choice or only allow survival of cells that are already lineage-restricted. Here, we used bioimaging approaches that allow the continuous long-term observation of individual differentiating mouse HPCs. We demonstrate that the physiological cytokines, macrophage colony-stimulating factor and granulocyte colony-stimulating factor, can instruct hematopoietic lineage choice.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
colony-stimulating factor; factor-receptor; in-vivo; cells; differentiation; progenitors; commitment; macrophage; granulocyte; expression
ISSN (print) / ISBN
0036-8075
e-ISSN
1095-9203
Journal
Science
Quellenangaben
Volume: 325,
Issue: 5937,
Pages: 217-218
Publisher
American Association for the Advancement of Science (AAAS)
Reviewing status
Peer reviewed
Institute(s)
Institute of Stem Cell Research (ISF)