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Open Access Green as soon as Postprint is submitted to ZB.
Signalling by O2- and NO: How far can either radical, or any specific reaction product, transmit a message under in vivo conditions.
Chem. Biol. Interact. 90, 35-45 (1993)
With regard to the stability of the NO. radical as a chemical entity, it is without doubt able to serve as an intra- as well as an intercellular messenger. The radical O2-., in contrast, does not seem to be suited to far-range signalling in the vascular system. Its short chemical half-life, which is limited by the presence of various reactive blood constituents to below 50 ms, results in a free diffusion path length of less than 40 microns, i.e. only the distance between just a few cells. While accelerated 'downstream' transport by arterial blood may help to extend the action sphere, there is no possibility for O2-. to serve as a signal in an upstream direction. The estimates presented, however, do not invalidate arguments for a possible role of superoxide anions in intra- or pericellular signalling phenomena. Cross-talk between NO.- and O2-.-dependent signal routes, e.g. by peroxynitrite formation, is unlikely to be a relevant process under the conditions which prevail in the vascular system.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Oxygen radicals; Nitric oxide; Superoxide anion; Peroxynitrite; Inter-and intracellular signalling
ISSN (print) / ISBN
0009-2797
e-ISSN
1872-7786
Journal
Chemico-Biological Interactions
Quellenangaben
Volume: 90,
Issue: 1,
Pages: 35-45
Publisher
Elsevier
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Radiation Biology (ISB)