PuSH - Publication Server of Helmholtz Zentrum München: Identification of a novel noncoding RNA gene, NAMA, that is downregulated in papillary thyroid carcinoma with BRAF mutation and associated with growth arrest.

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Yoon, H.* ; He, H.* ; Nagy, R.* ; Davuluri, R.* ; Suster, S.* ; Schoenberg, D.* ; Pellegata, N.S. ; de la Chapelle, A.*

Identification of a novel noncoding RNA gene, NAMA, that is downregulated in papillary thyroid carcinoma with BRAF mutation and associated with growth arrest.

Int. J. Cancer 121, 767-775 (2007)

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Open Access Green as soon as Postprint is submitted to ZB.

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In search of tumor suppressor genes in papillary thyroid carcinoma (PTC), we previously used gene expression profiling to identify genes underexpressed in tumor compared with paired unaffected tissue. While searching for loss of heterozygosity (LOH) in genomic regions harboring candidate tumor suppressor genes, we detected LOH in a approximately 20 kb region around marker D9S176. Several ESTs flanking D9S176 were underexpressed in PTC tumors, and for one of the ESTs, downregulation was highly associated with the activating BRAF mutation V600E, the most common genetic lesion in PTC. A novel gene, NAMA, (noncoding RNA associated with MAP kinase pathway and growth arrest) containing the affected EST was cloned and characterized. NAMA is weakly expressed in several human tissues, and the spliced forms are primarily detected in testis. Several characteristics of NAMA suggest that it is a nonprotein coding but functional RNA; it has no long open reading frames (ORFs); the exons exhibit low sequence identity in the evolutionarily conserved regions; it is inducible by knockdown of BRAF, inhibition of the MAP kinase pathway, growth arrest and DNA damage in cancer cell lines. We suggest that NAMA is a noncoding RNA associated with growth arrest.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords papillary thyroid carcinoma; noncoding RNA; BRAF; NAMA; growth arrest

ISSN (print) / ISBN 0020-7136

e-ISSN 1097-0215

Journal International Journal of Cancer

Quellenangaben Volume: 121, Issue: 4, Pages: 767-775

Publisher Wiley

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Pathology (PATH)