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Pfister, K.* ; Radons, J.* ; Busch, R.* ; Tidball, J.G.* ; Pfeifer, M.* ; Freitag, L.* ; Feldmann, H.J.* ; Milani, V. ; Issels, R.D. ; Multhoff, G.

Patient survival by Hsp70 membrane phenotype: Association with different routes of metastasis.

Cancer Cytopathol. 110, 926-935 (2007)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Heat shock proteins (HSPs) play important roles in tumor immunity. The authors prospectively investigated the correlation between the tumor-specific Hsp70 membrane expression as an independent clinicopathological marker and overall survival in tumor entities that differ in their route of metastasis. METHODS: Hsp70 membrane expression was examined by flow cytometry in 58 colon, 19 gastric, 54 lower rectal carcinoma, and 19 squamous cell carcinoma specimens and the corresponding normal tissues at time of first diagnosis. Kaplan-Meier survival curves were analyzed to determine the relation of Hsp70 expression to the patients' prognosis. RESULTS: An Hsp70 membrane-positive phenotype was found in 40% (colon), 37% (gastric), 43% (lower rectal), and 42% (squamous cell) of the analyzed tumor specimens. None of the corresponding normal tissues was found to be Hsp70 membrane-positive. In patients with colon (P = .032) and gastric (P = .045) carcinomas, an Hsp70 membrane expression correlated significantly with an improved overall survival; a negative association was seen in lower rectal (P = .085) and squamous cell carcinoma (P = .048). CONCLUSIONS: The authors hypothesized that differing relations between surface expression of Hsp70 on tumor cells and clinical outcomes may reflect differences in the route of metastases. Colon and gastric carcinomas metastasize into the liver where hepatic natural killer cells may have the capacity to recognize and kill Hsp70 membrane-positive tumor cells and thus account for a better overall survival.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Hsp70; clinical trial; prognostic marker; overall survival
ISSN (print) / ISBN 1934-662X
e-ISSN 1097-0142
Journal Cancer Cytopathology
Quellenangaben Volume: 110, Issue: 4, Pages: 926-935 Article Number: , Supplement: ,
Publisher Wiley
Reviewing status Peer reviewed
Institute(s) CCG Innate Immunity in Tumor Biology (PATH-KTB)
CCG Tumor Therapy with Hyperthermia (IMI-KTH)